[5] In 1905, the college purchased and relocated to a 51-acre (21 ha) tract located in Allentown's West End, which continues to serve as the present-day campus.

[7] The offerings for adult education outside of the traditional baccalaureate track evolved over the years through various titles, including an "Extension" school.

During the 2024 pro-Palestinian campus protests, the college fired its Jewish anthropology professor, Maura Finkelstein, for sharing a social media post by Palestinian poet Remi Kanazi who wrote, "Do not cower to Zionists.

[9][10] A Title IX complaint letter concerning “a Jewish anti-Zionist professor on campus who has written articles praising Hamas ..

The letter seeks the professor’s removal.”[9] Muhlenberg's current 82-acre (33 ha) campus is located in a residential neighborhood in Allentown's West End.

The campus includes buildings with distinctive traditional European and Protestant red doors laid out on several college quads.

The central part of the park-like campus is the college green, which incorporates public art, including Victor's Lament by sculptor Mark di Suvero, which incorporates a red I-beam and is a tribute to the history of steelmaking in Allentown and the surrounding Lehigh Valley during the 20th century.

It is named for David A. Miller (class of 1894), the first reporter for The Morning Call, an Allentown-based daily newspaper founded in 1883.

[6] Muhlenberg's Polling Institute teams with the newspaper to periodically publish surveys of preferences and trends among Pennsylvanians, especially in the Lehigh Valley.

[16] In August 2004, the Life Sports Center was expanded by 39,000 square feet (3,600 m2), adding a new indoor field house, gymnasium, cafe, health classrooms, and a pool.

[17] Muhlenberg College offers bachelor's degrees with academic focuses on liberal arts education and pre-professional studies.

Muhlenberg is primarily a regional college, with 72% of incoming freshmen coming from Pennsylvania, New Jersey, or New York state.

Both men's and women's teams exist for basketball, cross country, golf, lacrosse, soccer, tennis, track and field, and wrestling.

[28] In his first season, he guided the Mules to a 9–1 record[29] and a national championship with Muhlenberg defeating St. Bonaventure University in the Tobacco Bowl.

In 2007, the Mules again won the Centennial Conference and received another berth in the NCAA playoffs, winning their first-round game before falling in the second round.

In the 20th century, at least three Muhlenberg players went on to play in the National Football League: Sisto Averno (with the Baltimore Colts, Dallas Texans, and New York Yanks between 1950 and 1954), Charlie Copley (with the Akron Pros and Milwaukee Badgers between 1920 and 1922), and Tony Zuzzio (with the Detroit Lions in 1942).

Since the 2000 season, Muhlenberg has compiled a 66–28 overall record in the Centennial Conference, second-best among all active and former members behind only Johns Hopkins University.

The student-run radio station, WMUH, which broadcasts at 91.7FM, is operated year-round by both students and volunteers from the surrounding Lehigh Valley community.