Muleshoe High School is a public high school located in Muleshoe, Texas (USA) and classified as a 3A school by the UIL.

It is part of the Muleshoe Independent School District located in northwest Bailey County.

[1] The school received an overall rating of "A" from the Texas Education Agency for the 2021–2022 school year.

[3] The Muleshoe Mules compete in the following sports [4]

This article about a high school in Texas is a stub.