The high bay is certified for the processing of hazardous materials such as high-pressure gasses, hypergolic propellant, ammonia, oxygen, and fluorocarbons.

[5] After its construction, the MPPF was used for the processing of both Space Shuttle and Launch Services Program payloads.

The MPPF will also be used to de-service Orion capsules that have returned from space and remove any residual flight commodities.

[2] Due to the hazardous materials involved, loading and unloading of flight commodities will be remotely monitored and controlled from one of the firing rooms inside the Launch Control Center and performed by technicians wearing Self Contained Atmospheric Protective Ensemble (SCAPE) hazmat suits.

[2] On January 16 2021, The Artemis 1 Orion spacecraft began fueling and pre-launch servicing in the MPPF following a handover to exploration ground systems.