The River Musquaro flows south in the municipality of Côte-Nord-du-Golfe-du-Saint-Laurent, Quebec, in the Le Golfe-du-Saint-Laurent Regional County Municipality, in the administrative region of Côte-Nord (North-Shore), in Quebec, in Canada.

The main body of water feeding the Musquaro river is the Musquaro Lake including a bay in the south where is its mouth, which is about 32.5 kilometres (20.2 mi) in a direct line northeast of the village of Kebaska.

The river empties into the Bay Kauahinekaut, near Island Menahkunakat, Kahakaut and Mantuh, of the Washicoutai archipelago.

The ghost hamlet Musquaro is at the mouth of the river (between La Romaine and Kegaska), on the site of an old trading post established around 1710 by the French.

In 1780, the equivalent of the territory of Canton Musquaro was granted to the Company of Quebec Labrador.