It was originally released as the second official single of 50 Cent's scrapped studio album Street King Immortal, but was later removed from the project.

The song premiered on American radio station Hot 97, and was made available for digital download on iTunes Store on November 26, 2012.

[3] Although without a confirmed name, the single was announced on September 30, 2012, by 50 Cent himself in an interview with the radio station Channel 4 FM, with host Chris Birks.

[4] While confirming the name of the single, 50 Cent has revealed, during an interview while he was in France, that the beat of "My Life" was taken from Dr. Dre's long-awaited (but now cancelled) album Detox.

Recorded in 2010, it finds the two rappers spitting about the pressures of fame, in contrast with Eminem and 50's past collaborations, which focused on menacing wordplay.

50 Cent raps about pressures of fame, rifting on his meteoric 2003 rise and former G-Unit artists Game and Young Buck, who he feels took advantage of his creative generosity.

He also said: "Maroon 5's Adam Levine provides the pop backbone to a trio of surly verses from 50 Cent and Eminem, with the latter thrusting himself full force into lines".

I tried to help niggas get on, they turned around and spitRight in my face, so Game and Buck both can suck a dickNow when you hear 'em it may sound like they on some other shit'Cause I'm not writing anymore, they not making hitsGame responded to 50 Cent's comments in an interview with American radio station Power 106, saying he might have to make a sequel to "300 Bars and Runnin", finally killing 50 Cent and G-Unit.

50 Cent raps his first verse, walking inside the building illuminated by the chopper, going to find boxer Andre Dirrell.

[16] The song was debuted on American reality talent show The Voice, with a performance by 50 Cent and Adam Levine on November 26, 2012.