MyRF is a transcription factor that promotes the expression of many genes important in the production of myelin.

Following ablation of MYRF the expression of myelin genes such as PLP1, MBP, MAG and MOG drops rapidly.

[7] Mice that lose MYRF during adulthood present with a severe demyelination similar to that seen in animal models of multiple sclerosis.

[8] Animals with repressed Myrf in a proportion of oligodendrocyte precursor cells showed a delayed functional recovery from spinal cord injury.

[11] Myrf has been shown to be significantly downregulated in a mouse model carrying the same mutation in the NPC1 protein that is underlying Niemann-Pick type C1 disease, a neurodegenerative process in which dysmyelination is a main pathogenic factor.