It is located very close to the famous Mpilo Hospital of Bulawayo.
In the history of the Ndebele Kingdom, Mzilikazi High School draws most of its students from local feeder primary schools named after other Ndebele Royal figures, such as Mzilikazi himself; his son, Lobhengula; Lobhengula's Queen, Lozikeyi; and other leaders, such as Lotshe.
Some of Zimbabwe's top footballers were groomed here, like Peter Ndlovu[1] (who has played for Coventry City FC, Birmingham City FC, and Huddersfield FC and is currently plying his trade in South Africa), the late Benjamin Konjera, and the late Adam Ndlovu.
Yvonne Vera, the late internationally recognised novelist, and Prof Welshman Ncube, law professor and prominent opposition politician, are also alumni.
NoViolet Bulawayo, the famous novelist, also attended the school.