Just north of Battle Creek, it intersects with US 275, where this segment terminates for about 15 miles (24 km).

[1][2] The middle segment of Nebraska Highway 121 begins at NE 13 northwest of Pierce.

NE 121 runs concurrently with US 20 for about 3.5 miles (5.6 km) to the east, before splitting and continuing northward.

Further north, it will meet NE 84 and the segment will terminate at that point, resuming about 10 miles (16 km) to the northeast.

It heads northward from Crofton through farmland, passing by the Lewis and Clark State Recreation Area and Gavins Point Dam.