[3][4] Pierce County is part of the Norfolk, NE Micropolitan Statistical Area.

In the Nebraska license plate system, Pierce County is represented by the prefix 40 (it had the 40th-largest number of vehicles registered in the county when the license plate system was established in 1922).

Some of Pierce County's earliest settlers were German Lutheran colonists who had traveled from Ixonia, Wisconsin, and had founded the nearby town of Norfolk.

[5] The Pierce County terrain consists of low rolling hills, sloping to the east and southeast.

Most of the county's area is devoted to agriculture, often under central pivot irrigation.