[3] Madison County is part of the Norfolk, NE Micropolitan Statistical Area.

In the Nebraska license plate system, Madison County is represented by the prefix 7 (the county had the seventh-largest number of vehicles registered in the state when the license plate system was established in 1922).

The Elkhorn River runs eastward across the upper central portion of the county.

[5] As of the 2000 United States Census,[13] there were 35,226 people, 13,436 households, and 8,894 families in the county.

The 2013 film Nebraska is set mostly in Madison County, in the fictional town of Hawthorne.