The enzyme N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4)[1][2][3] catalyzes the chemical reaction of cleaving off the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of the macromolecule chondroitin sulfate and, similarly, of the D-galactose 6-sulfate units of the macromolecule keratan sulfate.
This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds.
Morquio syndrome is a rare birth defect caused by a deficiency in this essential enzyme.
[4][5] Treatment options include enzyme replacement therapy with a synthetic version of the enzyme called elosulfase alfa.
This EC 3.1 enzyme-related article is a stub.