The enzyme N-acetylneuraminate lyase (EC 4.1.3.3) catalyzes the chemical reaction This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds.

The systematic name of this enzyme class is N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming).

This enzyme participates in aminosugars metabolism.

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1F5Z, 1F6K, 1F6P, 1F73, 1F74, 1F7B, 1FDY, 1FDZ, 1HL2, and 1NAL.

This EC 4.1 enzyme-related article is a stub.