In enzymology, a NADPH—hemoprotein reductase is an enzyme that catalyzes the chemical reaction The three substrates of this enzyme are NADPH, H+, and oxidized hemoprotein, whereas its two products are NADP+ and reduced hemoprotein.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a heme protein as acceptor.

The systematic name of this enzyme class is NADPH:hemoprotein oxidoreductase.

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1AMO, 1B1C, 1J9Z, 1JA0, 1JA1, 1YQO, 1YQP, 2BF4, 2BN4, and 2BPO.

This EC 1.6 enzyme-related article is a stub.