In enzymology, a NADPH dehydrogenase (EC 1.6.99.1) is an enzyme that catalyzes the chemical reaction The 3 substrates of this enzyme are NADPH, H+, and acceptor, whereas its two products are NADP+ and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors.

The systematic name of this enzyme class is NADPH:acceptor oxidoreductase.

Other names in common use include

This EC 1.6 enzyme-related article is a stub.