Its eastern terminus was at a junction with NY 270 in the Amherst hamlet of Getzville.

The former routing of NY 356 east of the Tonawanda city limits is now maintained by Erie County.

NY 356 met Sweet Home Road, a local highway leading to the main campus of SUNY Buffalo, and crossed over Ellicott Creek shortly afterward.

[1] On April 1, 1980, ownership and maintenance of NY 356 between the Tonawanda city line and US 62 was transferred from the state of New York to Erie County as part of a highway maintenance swap between the two levels of government.

The portion of NY 356's former routing that traversed Ellicott Creek was dismantled as part of Interstate 990's construction.