We can say that NamiRNA and enhancer mutually affect each other to form a positive feedback network and together play regulatory functions on gene expression.
[citation needed] Traditional theory holds that miRNAs play inhibitory functions in the cytoplasm by binding the 3’ UTR of targeted mRNA and downregulate gene transcription.
The discovery of NamiRNAs provides a brand-new idea that miRNAs can also play positive roles on gene expression in transcriptional level in the nucleus.
Meanwhile, a functional network between NamiRNAs and enhancers is put forward to illustrate their roles for the positive regulation of their targeted gene transcription.
NamiRNA enhancer target gene activation network demonstrates the new function of miRNA located in the nucleus.