When applied to the skin as a topical ointment, it is used to mitigate blistering from poison ivy, oak, and sumac.

[citation needed] When combined with nystatin, it is used to treat skin infections with discomfort from fungus, though it should not be used on the eyes.

As an intravitreal injection, triamcinolone acetonide has been used to treat various eye diseases and has been found useful in reducing macular edema.

A systematic review did not find any evidence of any benefit in preventing vision loss in eyes treated with triamcinolone acetonide over placebo, for patients with age-related macular degeneration.

[18] Triamcinolone acetonide is also administered via intralesional injection in the treatment of hypertrophic and keloid scars.

[23] In relation to this, triamcinolone acetonide can produce endocrine side effects like ovulation inhibition and menstrual irregularities.