The northern terminus is in the Millard neighborhood of Omaha at an intersection with U.S. Highway 275 (US 275) and N-92.

The two highways overlap, first by going north and then by going west, into Pawnee City.

The two highways overlap going north out of Pawnee City and separate near Table Rock, Nebraska.

[1][3] N-50 continues due north from Syracuse, meeting US 34 near Avoca.

N-50 then goes northeast briefly and turns north to go through Springfield, where the highway becomes divided.