The third segment begins at U.S. Highway 77 south of Wahoo and ends at Main Street in Louisville.

Nebraska Highway 66 begins at an intersection with NE 14 south of Central City.

[1][2] The middle segment of Nebraska Highway 66 begins at NE 15 west of Dwight.

Southwest of Louisville, the route intersects with NE 50 and runs concurrently northward with it for just over a mile.

[1][4] Still in Louisville, the far eastern segment of N-66 starts at the intersection with Koop Avenue and Walnut Street.