[2] Needmore is located slightly east of the center of the county, around 13 miles (21 km) south of Muleshoe, the county seat, and 6 miles (10 km) north of the Muleshoe National Wildlife Refuge.

It is located at the intersection of Texas State Highway 214 and Farm to Market Road 298 between the small communities of Baileyboro to the west and Circle Back, 4 mi (6.4 km) to the east.

The terrain surrounding Needmore consists of level plains that at one time were covered with grassland vegetation.

Today, except the Muleshoe National Wildlife Refuge, the shortgrass prairie has been replaced by plowed cropland, where cotton, sorghum, and winter wheat are grown.

Some of the larger saline playas provide an important refuge for migratory waterfowl flying between Canada and Mexico, such as tens of thousands of sandhill cranes.