[3] Although no empirical data exist to test the hypothesis, many nematologists assume and circumstantial evidence suggests the "fiery serpents" to be the Guinea worm, Dracunculus medinensis, as this nematode is known to inhabit the region near the Red Sea.
"Sowed cockle, reap'd no corn," a line by William Shakespeare penned in 1594 in Love's Labour's Lost, Act IV, Scene 3, most certainly has reference to blighted wheat caused by the plant parasite, Anguina tritici.
[15] Needham[13] (1743) solved the "riddle of cockle" when he crushed one of the diseased wheat grains and observed "Aquatic Animals...denominated Worms, Eels, or Serpents, which they very much resemble."
[16] From 1750 to the early 1900s, nematology research continued to be descriptive and taxonomic, focusing primarily on free-living nematodes and plant and animal parasites.
[citation needed] Kuhn[18] (1874) is thought to be the first to use soil fumigation to control nematodes, applying carbon disulfide treatments in sugar beet fields in Germany.
[15] In this same year, Nathan Cobb (1918) published his Contributions to a Science of Nematology and his lab manual "Estimating the Nema Population of Soil.
Accounts of the history of nematology (the few that exist) mention three major events occurring between 1926 and 1950 that affected the relative importance of nematodes in the eyes of farmers, legislators and the U.S. public in general.
[15][17][21] These events contributed to a shift from broad taxonomy-based nematology research to deep, yet focused investigations of plant parasitic nematodes, especially the control of agricultural pests.