The N4016 is a 12-meter long and 2.5-meter wide bus, commonly powered by either a MAN or DAF engine, and equipped with a Voith or ZF Friedrichshafen transmission.

This model of bus is known for its spacious seating, typically accommodating 31 to 39 passengers, along with a large standing capacity.

Notable features of the N4016 include a double-curvature windscreen, a separately mounted destination sign, and a uniquely rounded roof dome.

Twelve were sold in the United Kingdom, all delivered to Merseybus for use on Merseytravel's SMART bus network in Liverpool.

[3] Poznań-based tram and bus operator, Miejskie Przedsiębiorstwo Komunikacyjne w Poznaniu, purchased 32 Neoplan N4016s between 1996 and 1999.