Athletes from the former Netherlands Antilles competed at the 2011 Pan American Games in Guadalajara, Mexico from October 14 to 30, 2011, about one year after the dissolution of the country.

Hubert Isenia was the Chef de mission of the team.

[1] Athletes from the Netherlands Antilles qualified one male cyclist in road cycling.

[1] Athletes from the Netherlands Antilles qualified two swimmers.

[3] The Netherlands Antilles received a wildcard to send one male taekwondo athlete.