These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively.

The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer's disease.

[7] Beta-synuclein is a synuclein protein found primarily in brain tissue and is seen mainly in presynaptic terminals.

Beta-synuclein is predominantly expressed in the neocortex, hippocampus, striatum, thalamus, and cerebellum.

Thus, beta-synuclein may protect the central nervous system from the neurotoxic effects of alpha-synuclein and provide a novel treatment of neurodegenerative disorders.