Route 880 is a 65.3-kilometre (40.6 mi) long east to west secondary highway in the south-eastern portion of New Brunswick, Canada.

The route's northeastern terminus is in Second North River at Route 112, where is travels southwest along the North River before crossing it and entering Lewis Mountain.

It continues through Dobsons Corner, Upper Ridge, and Hicksville, and it briefly merges with Route 885 in Havelock.

It continues past Perry Settlement, Cosman Settlement, and Head of Millstream, Gibbon, Summerfield, Pleasant Ridge, and Centreville.

It then follows the Millstream River to Berwick and Route 10.