New Madrid County Central High School is a secondary school located in New Madrid County, Missouri.

It serves grades 9–12 and is located just outside Howardville, Missouri.

The school became county-wide in 1980 when New Madrid, Lilbourn, and Parma High Schools (Matthews joined in 1983) all combined making New Madrid County Central High School.

The high school principal is Justin Poley.

This Missouri school-related article is a stub.