The Brandywine Highway is a north–south expressway in the vicinity of the city of Binghamton, New York, in the United States.

The highway is maintained by the New York State Department of Transportation and extends for 3.95 miles (6.36 km) through Downtown Binghamton and the neighboring village of Port Dickinson.

North of Frederick Street, the highway connects to the conjoined routes of I-81 and NY 17 by way of a cloverleaf interchange.

Just north of the cloverleaf's northern tip is a simpler diamond interchange between NY 7 and Bevier Street.

NY 7 becomes limited-access once more, meeting a pair of service roads that serve Hillcrest before merging with I-88 just north of the Port Dickinson village limits in the town of Fenton.