Continuing on, NY 434 serves a housing tract and a cluster of commercial properties at the southeastern edge of the village before heading into less developed areas of the town.

The route continues through forests and mostly undeveloped fields, serving exit 65 of I-86/NY 17 and passing by Owego Town Court ahead of another bend in the river.

Past the marsh, the valley swerves southward for a second time, taking the Susquehanna River and the two roads alongside it into an area with firmer ground.

[3] The highway heads generally southeasterly through the community to Apalachin's central business district, largely centered around NY 434's junction with County Route 41 (CR 41).

Occasional stretches of homes continue to follow the route to the county line, where the road widens from two to four lanes and becomes a divided highway.

The homes alongside the road are replaced by businesses in the hamlet of Vestal, the first of several large communities that NY 434 serves in Broome County's progressively widening river valley.

The pair of plazas feature several national chain stores, such as Walmart, Target, Sam's Club, and Lowe's, and a handful of others are located nearby at various points along NY 434.

At this point, the businesses begin to taper off, giving way to dense residential neighborhoods as the road crosses into the Binghamton city limits.

[3] NY 434 remains a four-lane divided highway for its first 2 miles (3.2 km) in the city, following the Susquehanna River along the north edge of a vast neighborhood that comprises the south half of Binghamton.

It soon approaches the vicinity of downtown Binghamton, where the route connects to Pennsylvania Avenue by way of an interchange located across the river from the city's center.

Another grade-separated junction with Conklin Avenue follows, at which point NY 434 turns northward and crosses the river into downtown as State Street.

NY 434 continues on, narrowing to two divided then undivided lanes for its final two blocks as it passes the Broome County Veterans Memorial Arena and ends at a junction with US 11 (Court Street).