Crossing over railroad tracks into the hamlet of East Waverly, the route becomes commercial, passing south of Dodge Pond.

During this southeastern stretch, the route soon begins to parallel the Norfolk Southern-owned Southern Tier Line (ex-Erie Railroad tracks), becoming a two-lane residential street through Barton.

NY 17C soon crosses an intersection with the southern terminus of County Route 9 (CR 9; Ellis Creek Road), entering the hamlet of Ellistown.

[4] In Tioga Center, NY 17C is a two-lane residential street, intersecting with Fifth Avenue, which connects to a large commercial section.

Paralleling the tracks and the Susquehanna River, NY 17C continues northeast, bending further eastward through a string of fields.

Just after crossing the railroad tracks, NY 17C intersects with the terminus of CR 23 (Glen Mary Drive).

Now running northeast, the route is south and east of the railroad tracks, changing names to Waverly Road as it crosses through Tioga as a two-lane residential street.

After CR 43, NY 17C turns eastward, passing several spurts of commercial strips before entering the village of Owego.

Paralleling the Norfolk Southern tracks once again, NY 17C proceeds southeast alongside a stretch of houses near the Susquehanna River, crossing into the town of Owego.

Running alongside the tracks and the Susquehanna again, the route makes another stretch to the northeast, bending southeast through Owego.

NY 17C continues eastward through the town of Owego, running on an embankment high over the Norfolk Southern tracks, remaining a two-lane residential road as it bends northeast.

[4] Crossing into Broome County, NY 17C abruptly climbs up the side of Bornt Hill and parallels the tracks and river into the town of Union, entering the urban core of the Binghamton metropolitan area.

The route, still bearing the name of Campville Road, runs over the hill to the north and west of Tri-Cities Airport and the Triple Cities to the east become visible for the first time.

The route becomes a commercial village street before intersecting with NY 26, Nanticoke Avenue, at the center of downtown Union.

Each section runs along opposite sides of the freeway; as such, each serves as a frontage road for exit 69 of the expressway.

The two directions of NY 17C come back together in the hamlet of Westover, located about 1.5 miles (2.4 km) to the east on the north bank of the Susquehanna River.