NY 201 bends northeast, crossing the Susquehanna River via the C. Fred Johnson Bridge.

Continuing north through Johnson City, ramps from Riverside Drive merge in northbound, at which point, NY 201 crosses over the former Delaware, Lackawanna and Western Railroad main line tracks.

While crossing over the tracks, ramps accessing the Southern Tier Expressway (exit 70N of NY 17).

[7] A new highway crossing the Susquehanna River from Vestal to Johnson City opened to traffic in 1954.

[8][9] In September 1971, the Vestal–Johnson City arterial and the portion of Riverside Drive north of that highway was redesignated as NY 201.