Ngee Ann City was officially opened by Prime Minister Goh Chok Tong on 21 September 1993.

In 2005, the shopping mall opened an art and creativity section on the 4th floor called iFORUM, the first of its kind in Singapore.

The building is connected by underpasses to Wisma Atria, ION Orchard, Wheelock Place, Isetan and Lucky Plaza.

[4] The two towers of Ngee Ann City were intended by the designer to symbolise Chinese door gods, representing strength, generosity, and unity.

Tenants in the office tower include Takashimaya Singapore, Books Kinokuniya, Metro department store, Ngee Ann Development, some private office tenants and a medical floor on Level 8 of Tower B. Toshin Development Singapore Pte.

Ltd. manages the speciality stores area of Takashimaya Shopping Centre located from basement 2 to level 4 of Ngee Ann City, covering over 370,000 square feet.