In enzymology, a nicotinate N-methyltransferase (EC 2.1.1.7) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are S-adenosyl methionine and nicotinate, whereas its two products are S-adenosylhomocysteine and N-methylnicotinate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases.

The systematic name of this enzyme class is S-adenosyl-L-methionine:nicotinate N-methyltransferase.

This enzyme participates in nicotinate and nicotinamide metabolism.

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 5MHT.