A 2024 study from the University of Louisville raised concerns about the cardiovascular effects of nicotine salts, particularly when used in pod-based devices like Juul.

The study found that higher concentrations of nicotine salts may increase the risk of cardiac arrhythmias.

This study focused on "fourth-generation" e-cigarette devices and identified biomarkers indicative of airway injury and immune system suppression.

[13] Traditional cigarettes provide high levels of nicotine, but with the taste of tobacco and paper smoke which many may find undesirable.

Nicotine salts in aerosol form do not generally generate the sensation of irritation in the chest and lungs that regular cigarettes do.

[9] Tested show that the pod mods Juul, Bo, Phix, and Suorin contain nicotine salts in a solution with propylene glycol and glycerin.

[19] The trade of nicotine salts has grown significantly with the rising popularity of vaping devices and e-cigarettes.

Various online retailers offer nicotine salts in different concentrations and formulations, catering to both consumers and manufacturers.

[20] Recent studies have raised concerns about the potential health risks associated with certain nicotine salt formulations.