The Nijenhuis is an estate near the village Heino in the province of Overijssel, The Netherlands.

The estate holds an avezathe (a kind of manor house, typical for Overijssel).

The building is in use by Museum de Fundatie as an exhibition space for visual art.

Part of the gardens house a collection of sculptures.

From 1958 to 1984 Dirk Hannema lived at the estate.