[1] The Nipissis drains a region of 4,196 square kilometres (1,620 sq mi), making it the most important tributary of the Moise River.

According to the 1969 Répertoire géographique du Québec the river that runs for a little more than 60 kilometres (37 mi) south to the Siamois lakes is called the Matinipi.

[9] In February 2019 the council of the Uashat mak Mani-Utenam band formally took possession of the Moisie-Nipissis outfitter at the mouth of the Nipissis, with its sixteen salmon pits.

The government of Quebec paid the purchase cost based on an agreement reached with the Innu the previous year.

[10] In 1994 during a cross-country ski traverse Patrice Beaudet discovered that the Nipissis area had exceptional ice climbing lines.

[11] The shores of the river have many cliffs over 200 metres (660 ft) high, with about thirty sites suitable for ice climbing.

[11] The sites on the west bank of the river are hard to access due to deep snow, thick woods and difficult terrain.