[1][2][3] It usually occurs between sequences of DNA that have been previously duplicated through evolution, and therefore have low copy repeats (LCRs).
These repeat elements typically range from 10–300 kb in length and share 95-97% sequence identity.
This can give rise to rare genetic disorders, caused by the loss or increased copy number of genes within the deleted or duplicated region.
[1] Recurrent rearrangements are nucleotide sequence variations found in multiple individuals, sharing a common size and location of break points.
[4] Therefore, multiple patients may manifest with similar deletions or duplications, resulting in the description of genetic syndromes.