The non-histone proteins, are a large group of heterogeneous proteins that play a role in organization and compaction of the chromosome into higher order structures.
They play vital roles in regulating processes like nucleosome remodeling, DNA replication, RNA synthesis and processing, nuclear transport, steroid hormone action and interphase/mitosis transition.
This classification group also includes numerous other structural, regulatory, and motor proteins.
The methylation of non-histone proteins regulates responses to DNA damage including the modulation of DNA repair pathways in proliferating and post-mitotic neuronal cells.
[2] Hartwell, Leland; L. Hood; M. Goldberg; A. Reynolds; L. Silver; R. Veres (2004).