The four founding partners were: Friends of North York General (later to become the North York General Hospital Foundation); the Imperial Order Daughters of the Empire (IODE), a Canadian women's charitable organization; the Missionary Health Institute; and Volunteer Services.

Under the leadership of Colonel Clifford Sifton, plans were made and funds raised for a 70-bed community hospital on the corner of Leslie and Sheppard.

On March 15, 1968, Premier John Robarts officially dedicated North York General Hospital.

Dr. Donald Low recalls poring over patient charts throughout the Victoria Day weekend, held that year on 19 May, when he hypothesized that a disease that caused the emergency that the province had declared finished a few days earlier was actually still spreading among health-care workers and hospital patients.

[7] On December 10, 2017, the Reactivation Care Centre: A Central LHIN Hospitals Collaborative opened at 2111 Finch Avenue West.

[8] The General site is located at Leslie Street and Sheppard Avenue in north central Toronto.

In 1997 it became part of North York General Hospital (as NYGH-Branson Division) after the final report by the Health Services Retructuring Commission.

These services are aimed at seniors with medical or mental health problems that threaten their independence or the ability to live at home.