[1] The emergency department now treats 28,065 persons each year, while the hospital also houses the major transplantation service for Ontario, performing heart, lung, kidney, liver, pancreas, and small intestine, amongst others, for patients referred from all over Canada.

[4] In 2015, surgeons performed the world's first triple organ transplant (lung, liver and pancreas) in 19 year old Reid Wylie at Toronto General Hospital.

Currently, Sophie, Duchess of Edinburgh, as a member of the Canadian Royal Family, is patron of the hospital.

In 1855 a new home for the hospital was built on the north side of Gerrard Street, east of Parliament, using a design by architect William Hay.

In 1913, the hospital moved to College Street, near its current location, expanding and upgrading over the ensuing years.