Humber River Hospital is a major acute care hospital in Toronto, Ontario, Canada, located in the northwest part of Toronto, near Highway 401 and Keele Street.

Construction on the CA$1.6 billion facility began in October 2011 on the site of a former Ministry of Transportation of Ontario parking lot on Keele Street north of the 401 highway.

The new hospital was designed by HDR Architects, engineered by WSP and built by PCL.

[5] Ambulatory and Urgent Care services remained open at the York-Finch site, and the Humber Memorial site re-opened in 2016 to provide dialysis, out-patient physiotherapy and the Community Care Access Centre (CCAC) wound and skin clinic on a temporary basis.

[7] In 2017, the hospital opened its "Command Centre" that was built in collaboration with GE Healthcare.