These viruses are referred to as nucleocytoplasmic because they are often able to replicate in both the host's cell nucleus and cytoplasm.

These include four key proteins involved in DNA replication and repair: the enzymes DNA polymerase family B, the topoisomerase II A, the FLAP endonuclease and the processing factor proliferating cell nuclear antigen.

The class Pokkesviricetes infects familiar vertebrates, including multiple farm animals and humans.

Some of the symptoms for this flu include fever, high pulse, fast breathing, and it can cause death.

These symptoms can be similar to those from hog cholera, the difference is that the African swine flu can not be cured.

The Iridoviridae have linear double stranded DNA genomes up to 220 kilobases long and can code for about 211 proteins.

The replication cycle of this virus begins in the nucleus of the host and end in the cytoplasm.

Once it infects, viral replication takes place in virus factories in the cytoplasm.

They have linear double stranded DNA genomes with a length of 1,259,197 base pairs, which is larger than some small bacteria.

Once the virus infects the host, the replication cycle takes place in the cytoplasm.

[15] The pathway of DNA base excision repair (BER) was experimentally reconstituted using the purified recombinant proteins AP endonuclease (mvAPE), uracil-DNA glycosylase (mvUDG), and DNA polymerase X protein (mvPolX).

[15] Cafeteria roenbergensis, a giant virus of the Mimiviridae family, also encodes enzymes for DNA repair.

Later it appeared that the viruses of the Organic Lake Phycodna Group (OLPG) are more related to Mimiviruses than to Phycodnaviruses.

For this reason it has been proposed adding them to legacy Mimiviridae as new subfamily Mesomimivirinae in order to form the more comprehensive family Megaviridae.

[17][18][19][20][21][22] However, since the ICTV has created a new order Imitervirales officially containing the (legacy) Mimiviridae, proposed Mesomimivirinae are proposed to be upgraded as a new family Mesomimiviridae, i. e. as sister family of legacy Mimiviridae (within this order).

Like other giant viruses, it affects the host's nucleus and can take up to 15 hours to start infecting.

[24] Although it is found in water, it does not affect humans, it may actually help us by increasing the production of oxygen in aquatic environments.

For years this virus was believed to be frozen, but due to climate change it has begun to show up again.

Pithovirus, Iridoviridae–Ascoviridae and Marseillevirus form a PIM or MAPI clade (Pimascovirales[2]) in trees built from conserved proteins.

The origin of the NCLDVs may predate that of their eukaryotic hosts, judging from their RNA polymerase structures.