The Nurgan Regional Military Commission (Chinese: 奴兒干都指揮使司; pinyin: Nú'érgān dūzhǐhuī shǐsī) was a Chinese administrative seat established in Manchuria (including Northeast China and Outer Manchuria) during the Ming dynasty, located on the banks of the Amur River, about 100 km from the sea, at Nurgan city (modern Tyr, Russia).

[4][5] By 1409, the Yongle Emperor's government, which had already established relations with the Haixi and Jianzhou Jurchens in southern Manchuria, ordered Yishiha to start preparations for an expedition to the lower Amur River region, to demonstrate the power of the Ming Empire to the Nurgan Jurchen populating the area and induce them to enter into relations with the empire, and to ensure that they would not create trouble for the Ming state when the latter went to war with the Eastern Mongols.

[6] In 1413 Yishiha also visited the nearby coast of the Sakhalin Island, and granted Ming titles to a local chieftain.

[5] Some sources report a Chinese fort existed at Aigun for about 20 years during the Yongle era on the left (northwestern) shore of the Amur downstream from the mouth of the Zeya River.

[6][8] This time Yishiha's fleet included 50 big ships with 2,000 soldiers, and they actually brought the new chief (who had been living in Beijing) to Tyr.