[4] The Sisters of the Third Order of St. Francis was founded in Peoria on July 16, 1877, by Mother M. Frances Krasse, O.S.F., and Bishop John Lancaster Spalding.
The hospital in Rockford moved in 1963 to a new facility as present day OSF Saint Anthony Medical Center.
St. James Hospital was established in 1907 in Pontiac, Illinois, moving to a new facility in 2002 as present day OSF Saint James-John W. Albrecht Medical Center.
In 2009, Cardiovascular Institute, an OSF LLC, was organized to provide professional services of cardiologists in the Rockford, Illinois, area.
OSF Perinatal Associates, LLC, was organized to provide maternal fetal medicine physician services in the Peoria area.
In 2010, the OSF Multispecialty Group – Western Region, LLC, was organized for specialty physician services in the Galesburg, Illinois, area.
OSF Children's Medical Group – Congenital Heart Center, LLC, was organized to provide pediatric cardiology services in the Rockford, Illinois, area.
[11] In the spirit of Christ and the example of Francis of Assisi, the Mission of OSF HealthCare is to serve persons with the greatest care and love in a community that celebrates the Gift of Life.