The Ohio River Islands National Wildlife Refuge (ORINWR) is a National Wildlife Refuge (NWR) in non-contiguous sites consisting of islands along 362 miles (583 km)[2] of the Ohio River, primarily (85% of acreage)[3] in the U.S. state of West Virginia.

[4] Looking downstream, the refuge is currently located in parts of these counties: Beaver, Brooke, Ohio, Marshall, Wetzel, Tyler, Pleasants, Wood, Jackson, Mason, and Lewis.

The ORINWR was established in 1990 and consists of 3,354 acres (13.57 km2) of land and underwater habitat on twenty-two islands and four mainland properties.

The refuge headquarters with visitor center is located in Williamstown, West Virginia.

This article incorporates public domain material from websites or documents of the United States Fish and Wildlife Service.