Its eastern terminus is at a T-intersection with SR 148 approximately 5.25 miles (8.45 km) northeast of Beallsville.

No part of SR 145 is included as a part of the National Highway System.

[7] The SR 145 designation was applied in 1923.

It was originally routed from its southern terminus in Lower Salem to its junction with SR 78 in Lewisville.

[5][6] SR 145 was extended to the north in 1937, routed from SR 78 in Lewisville to then-SR 8 in Malaga.