It immediately crosses Salt Run before curving to climb a small hill.

After two switchback turns, SR 564 reaches the top of the hill and begins to slowly descend in elevation.

Just before the main Duck Creek, the route ends at SR 145 just outside the community of Harriettsville.

The entire route is two lanes wide and is located within very rural areas punctuated occasionally with small houses.

The route north of the former SR 563 near Middleburg has always been asphalt-paved, the portion south of there was paved by 1958.