Its eastern terminus is at the Pennsylvania state line just 0.50 miles (0.80 km) east of Lowellville.

Continuing east into Pennsylvania after SR 289 ends is locally-maintained Graham Road.

SR 289 runs entirely within the northeastern quadrant of Mahoning County.

The NHS is a network of highways identified as being most important for the economy, mobility and defense of the nation.

Originally, the highway was routed from the intersection with Wick Avenue, at the time a part of US 62/SR 7, and running southeasterly along its present alignment to its eastern terminus at the Pennsylvania state line just southeast of Lowellville.