Its southern terminus is at U.S. Route 50 approximately 9 miles (14 km) east of Downtown Cincinnati – this point also serves as the western termini for both SR 32 and SR 125; the route’s northern terminus is at its intersection with Vine and Seymour Streets.

[2] The NHS is a network of highways that are identified as being most important for the economy, mobility and defense of the nation.

The route heads northwest turning north towards Interstate 71.

[5] SR 561 was then extended to the south to its current terminus on a former segment of U.S. Route 50 in 1941.

[5] In 1947, the northern terminus was moved one mile (1.6 km) north of State Route 4.