From Greenville it continues southeast through Painter Creek and Laura to West Milton where it turns due east, passes over Interstate 75 to Tipp City and New Carlisle.

The portion of SR 571 between Union City and Greenville in Darke County is designated the "196th Light Infantry Brigade SP4 Robert L. Fowble Jr., and PFC Jack E. Beam Memorial Highway",[3] in honor of two U.S. Army soldiers from the same brigade who were killed by enemy fire while fighting in the Vietnam War.

[4] The portion of the route within Miami County is designated the "Robert E. Netzley Highway" in honor of the late former state representative.

In December 2023, the Ohio Department of Transportation (ODOT) revealed that it planned to replace the current flashing traffic-light-controlled intersection of SR 571 and SR 201 in Bethel Township, Miami County with a single-lane roundabout, pending funding.

The homeowner reported that the house had been struck twice in the 1960s and 1970s, with heavy damage in 1982; an additional collision, without significant injury, took place there in December 2023.