Its southern terminus is at State Route 528 about 2 miles (3.2 km) south of Middlefield.

The northern terminus is at Ravenna Road (Lake County Road 360, former State Route 44) about 4 miles (6.4 km) south of Painesville.

The route passes through one of the largest Amish settlements in Ohio; an Amish-run cheese factory is located at Nauvoo Road north of Middlefield.

SR 608 follows part of the Old State Road, which was constructed in 1805 between Painesville and Warren.

[5][6] The route was extended south to its current southern terminus, at SR 528, in 1965.